Zafrens maps continuous perturbation-response gradients across dense chemical analog series using a microchip-based system with 50,000 deterministic wells per chip — at reported 1/1000th the cost and 10,000x the throughput of traditional HTS, without robotics.
What is the problem?
Aging-related diseases and cancer share a common biology: loss of cellular homeostasis driven by interconnected master regulatory pathways. The therapeutic challenge is that these regulators — ATF4/ISR, METTL3, PRMT5, among others — require precise modulation rather than binary inhibition.
What is their solution?
Zafrens maps continuous perturbation-response gradients across dense chemical analog series using a microchip-based system with 50,000 deterministic wells per chip — at reported 1/1000th the cost and 10,000x the throughput of traditional HTS, without robotics. Critically, each experiment pairs cell painting with whole transcriptomics on the same samples, generating multi-modal readouts capturing both morphological and molecular responses.
