Forecast is a preclinical therapeutics platform that predicts clinical outcomes with precision, by defining in vitro biological correlates of clinical CNS symptoms.
What is the problem?
CNS diseases are a large area of unmet need, but clinical trial failures for neurotherapeutics remain >90%. Innovation has been blocked by the complex dynamical circuits that underpin brain pathophysiology, by preclinical disease models in animals that don’t recapitulate human biology, and by recruitment and endpoint variability in clinical trials that mask clear outcomes.
What is their solution?
Forecast is a preclinical therapeutics platform that predicts clinical outcomes with precision, by defining in vitro biological correlates of clinical CNS symptoms. We link drug chemistry to patient outcomes using a unique neural circuit readout leveraging the third of the brain that is largely ignored: astrocytes, homeostatic integrators of brain-wide neurochemical signals.
